Our group has collaborated with several researchers and published hundreds of research papers


Functioning Assessment

Short Test


Biological Rythm Interview of Assessment in Neuropsychiatry


BRIAN guide of admnistration 

Some of our

open-access papers

Frey BN, Vigod S, de Azevedo Cardoso T, Librenza-Garcia D, Favotto L, Perez R, Kapczinski F. The Early Burden of Disability in Individuals With Mood and Other Common Mental Disorders in Ontario, Canada. JAMA Netw Open. 2020 Oct 1;3(10):e2020213. doi: 10.1001/jamanetworkopen.2020.20213. PMID: 33104205; PMCID: PMC7588941.

Sehmbi M, Rowley CD, Minuzzi L, Kapczinski F, Kwiecien JM, Bock NA, Frey BN. Age-related deficits in intracortical myelination in young adults with bipolar disorder type I. J Psychiatry Neurosci. 2019 Mar 1;44(2):79-88. PubMed PMID: 30525334; PubMed Central PMCID: PMC6397039.

Duarte JA, Massuda R, Goi PD, Vianna-Sulzbach M, Colombo R, Kapczinski F, Gama CS. White matter volume is decreased in bipolar disorder at early and late stages. Trends Psychiatry Psychother. 2018 Oct-Dec;40(4):277-284. doi: 10.1590/2237-6089-2017-0025. PubMed PMID: 30570099.

de Ávila Berni G, Rabelo-da-Ponte FD, Librenza-Garcia D, Boeira MV, Kauer-Sant'Anna M, Passos IC, Kapczinski F. Potential use of text classification tools as signatures of suicidal behavior: A proof-of-concept study using Virginia Woolf's personal writings. PLoS One. 2018 Oct 24;13(10):e0204820. doi: 10.1371/journal.pone.0204820. eCollection 2018. Erratum in: PLoS One. 2018 Nov 16;13(11):e0207963. PubMed PMID: 30356303; PubMed Central PMCID: PMC6200194.

Yatham LN, Kennedy SH, Parikh SV, Schaffer A, Bond DJ, Frey BN, Sharma V, Goldstein BI, Rej S, Beaulieu S, Alda M, MacQueen G, Milev RV, Ravindran A, O'Donovan C, McIntosh D, Lam RW, Vazquez G, Kapczinski F, McIntyre RS, Kozicky J, Kanba S, Lafer B, Suppes T, Calabrese JR, Vieta E, Malhi G, Post RM, Berk M. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder. Bipolar Disord. 2018 Mar;20(2):97-170. doi: 10.1111/bdi.12609. Epub 2018 Mar 14. PubMed PMID: 29536616; PubMed Central PMCID: PMC5947163.

Ferrari P, Parisi MM, Colombo R, Becker M, Fries G, Ascoli BM, Géa LP, Anna MK, Kapczinski F, Klamt F, Guma FTCR, Rosa AR, Barbé-Tuana FM. Depression and Mania Induce Pro-inflammatory Activation of Macrophages Following Application of Serum from Individuals with Bipolar Disorder. Clin Psychopharmacol Neurosci. 2018 Feb 28;16(1):103-108. doi: 10.9758/cpn.2018.16.1.103. PubMed PMID: 29397672; PubMed Central PMCID: PMC5810451

Boeira MV, Berni GÁ, Passos IC, Kauer-Sant'Anna M, Kapczinski F. Virginia Woolf, neuroprogression, and bipolar disorder. Braz J Psychiatry. 2017 Jan-Mar;39(1):69-71. doi: 10.1590/1516-4446-2016-1962. Epub 2016 Jun 14. PubMed PMID: 27304258.

Pfaffenseller B, da Silva Magalhães PV, De Bastiani MA, Castro MA, Gallitano AL, Kapczinski F, Klamt F. Differential expression of transcriptional regulatory  units in the prefrontal cortex of patients with bipolar disorder: potential role of early growth response gene 3. Transl Psychiatry. 2016 May 10;6:e805. doi: 10.1038/tp.2016.78. PubMed PMID: 27163206; PubMed Central PMCID: PMC5070056.

Cao B, Bauer IE, Sharma AN, Mwangi B, Frazier T, Lavagnino L, Zunta-Soares GB, Walss-Bass C, Glahn DC, Kapczinski F, Nielsen DA, Soares JC. Reduced hippocampus  volume and memory performance in bipolar disorder patients carrying the BDNF val66met met allele. J Affect Disord. 2016 Jul 1;198:198-205. doi: 10.1016/j.jad.2016.03.044. Epub 2016 Mar 10. PubMed PMID: 27018938; PubMed Central PMCID: PMC5214589.

Yatham LN, Beaulieu S, Schaffer A, Kauer-Sant'Anna M, Kapczinski F, Lafer B, Sharma V, Parikh SV, Daigneault A, Qian H, Bond DJ, Silverstone PH, Walji N, Milev R, Baruch P, da Cunha A, Quevedo J, Dias R, Kunz M, Young LT, Lam RW, Wong  H. Optimal duration of risperidone or olanzapine adjunctive therapy to mood stabilizer following remission of a manic episode: A CANMAT randomized double-blind trial. Mol Psychiatry. 2016 Aug;21(8):1050-6. doi: 10.1038/mp.2015.158. Epub 2015 Oct 13. PubMed PMID: 26460229; PubMed Central PMCID: PMC4960445.

Cacilhas AA, Magalhães PV, Ceresér KM, Walz JC, Weyne F, Rosa AR, Vieta E, Kapczinski F. Validity of a short functioning test (FAST) in Brazilian outpatients with bipolar disorder. Value Health. 2009 Jun;12(4):624-7. doi: 10.1111/j.1524-4733.2008.00481.x. Epub 2009 Jan 12. PubMed PMID: 19900260.

Ascoli BM, Parisi MM, Bristot G, Antqueviezc B, Géa LP, Colombo R, Kapczinski F, Guma FTCR, Brietzke E, Barbé-Tuana FM, Rosa AR. Attenuated inflammatory response of monocyte-derived macrophage from patients with BD: a preliminary report. Int J Bipolar Disord. 2019 Jun 1;7(1):13. doi: 10.1186/s40345-019-0148-x.PubMed PMID: 31152269; PubMed Central PMCID: PMC6544740.

Cho CH, Jung SY, Kapczinski F, Rosa AR, Lee HJ. Validation of the Korean Version of the Biological Rhythms Interview of Assessment in Neuropsychiatry. Psychiatry Investig. 2018 Dec;15(12):1115-1120. doi: 10.30773/pi.2018.10.21.1. Epub 2018 Dec 19. PubMed PMID: 30602104; PubMed Central PMCID: PMC6318494.

Salagre E, Dodd S, Aedo A, Rosa A, Amoretti S, Pinzon J, Reinares M, Berk M, Kapczinski FP, Vieta E, Grande I. Toward Precision Psychiatry in Bipolar Disorder: Staging 2.0. Front Psychiatry. 2018 Nov 29;9:641. doi: 10.3389/fpsyt.2018.00641. eCollection 2018. Review. PubMed PMID: 30555363; PubMed Central PMCID: PMC6282906.

Syan SK, Smith M, Frey BN, Remtulla R, Kapczinski F, Hall GBC, Minuzzi L. Resting-state functional connectivity in individuals with bipolar disorder during clinical remission: a systematic review. J Psychiatry Neurosci. 2018 Aug;43(5):298-316. PubMed PMID: 30125243; PubMed Central PMCID: PMC6158027.

Pfaffenseller B, Kapczinski F, Gallitano AL, Klamt F. EGR3 Immediate Early Gene and the Brain-Derived Neurotrophic Factor in Bipolar Disorder. Front Behav Neurosci. 2018 Feb 5;12:15. doi: 10.3389/fnbeh.2018.00015. eCollection 2018. PubMed PMID: 29459824; PubMed Central PMCID: PMC5807664.

Pinto JV, Passos IC, Librenza-Garcia D, Marcon G, Schneider MA, Conte JH, da Silva JPA, Lima LP, Quincozes-Santos A, Kauer-Sant Anna M, Kapczinski F. Neuron-glia Interaction as a Possible Pathophysiological Mechanism of Bipolar Disorder. Curr Neuropharmacol. 2018;16(5):519-532. doi: 10.2174/1570159X15666170828170921. Review. PubMed PMID: 28847296; PubMed Central PMCID: PMC5997869.

Wollenhaupt-Aguiar B, Pfaffenseller B, Chagas VS, Castro MA, Passos IC, Kauer-Sant'Anna M, Kapczinski F, Klamt F. Reduced Neurite Density in Neuronal Cell Cultures Exposed to Serum of Patients with Bipolar Disorder. Int J Neuropsychopharmacol. 2016 May 31. pii: pyw051. doi: 10.1093/ijnp/pyw051. [Epub ahead of print] PubMed PMID: 27207915; PubMed Central PMCID: PMC5091826.

Vasconcelos-Moreno MP, Bücker J, Bürke KP, Czepielewski L, Santos BT, Fijtman A, Passos IC, Kunz M, Bonnín CD, Vieta E, Kapczinski F, Rosa AR, Kauer-Sant'Anna M. Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls. Braz J Psychiatry. 2016 Oct-Dec;38(4):275-280. doi: 10.1590/1516-4446-2015-1868. Epub 2016 Apr 19. PubMed PMID: 27096411.

Passos IC, Mwangi B, Cao B, Hamilton JE, Wu MJ, Zhang XY, Zunta-Soares GB, Quevedo J, Kauer-Sant'Anna M, Kapczinski F, Soares JC. Identifying a clinical signature of suicidality among patients with mood disorders: A pilot study using  a machine learning approach. J Affect Disord. 2016 Mar 15;193:109-16. doi: 10.1016/j.jad.2015.12.066. Epub 2016 Jan 1. PubMed PMID: 26773901; PubMed Central PMCID: PMC4744514.

Hallak JE, Crippa JA, Quevedo J, Roesler R, Schröder N, Nardi AE, Kapczinski F. National Science and Technology Institute for Translational Medicine (INCT-TM): advancing the field of translational medicine and mental health. Braz  J Psychiatry. 2010 Mar;32(1):83-90. PubMed PMID: 20339739.